Megaloblastic anemia from methophenobarbital.

By R. J. CALVERT, E. HUnwoilTil AND A. L. MACBEAN I HE OCCASIONAL DEVELOPMENT of megaloblastic anemia during the administration for months or years of certain anticonvubsant drumgs ( phenytom sodium and/or primidone, with or withoumt phenobarbital ) has been reviewed by Gydell#{176} and Newman and Sumner.11 Ouir report concerns an epileptic patient who presented as a gynecologic emergency with this blood disorder after eight years of treatment with phenyl-methyl barbituric acid ( “Rutonal” ) in standard dosage. This drug has not previoumsly been incrimiriated.